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Product Name
Thrombomodulin Rabbit pAb
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Gene ID
7056
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SwissProt ID
P07204
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Gene Name
THBD
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Alternative Names
CD 141; CD141; CD141 antigen; Fetomodulin; THBD; THRM; TM; AHUS 6; AHUS6; BDCA 3; BDCA3; THPH12; TRBM_HUMAN.
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Background
Thrombomodulin (TM), also called CD141, is a type I membrane receptor that is specific to endothelial cells. TM has a cysteine-rich extracellular domain with six EGF-like regions. It forms a complex with Thrombin, which activates Protein C to generate activated Protein C (APC), an anticoagulant enzyme. APC together with Protein S inhibits coagulation by inactivating Factors Va and VIIIa. Deletion of the TM gene results in embryonic lethality in mice.
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Research Field
Cardiovascular
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB,IHC-F,IHC-P,ICC/IF,ELISA
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/5000-1/10000
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Molecular Weight
Calculated MW: 61kDa
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Clonality
Polyclonal
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Clonality No.
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Isotype
IgG
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Immunogen
KLH conjugated synthetic peptide derived from mouse Thrombomodulin
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Purification
affinity purified by Protein A
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Storage
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.