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Product Name
Phospho-H2AX (Tyr143) Rabbit pAb
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Gene ID
3014
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SwissProt ID
P16104
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Gene Name
H2AX
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Alternative Names
Histone H2A.X (phospho T143); Histone H2A.X (phospho Thr143); H2AX_HUMAN; 2A.X variant histone; H2A.X; H2A/X; H2AFX; Histone H2AX;
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Background
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
IHC-F,IHC-P,ICC/IF,FC,ELISA
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Dilution Ratio
IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/5000-1/10000
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Molecular Weight
Calculated MW: 16kDa
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Clonality
Polyclonal
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Clonality No.
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Isotype
IgG
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Immunogen
KLH conjugated Synthesised phosphopeptide derived from human Histone H2AX around the phosphorylation site of Tyr143
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Purification
affinity purified by Protein A
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Storage
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.