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Product Name
Phospho-Tuberin (Thr1462) Rabbit pAb
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Gene ID
7249
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SwissProt ID
P49815
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Gene Name
TSC2
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Alternative Names
Tuberin(phospho T1462); Tuberin (phospho Thr1462); p-Tuberin (Thr1462); TSC2; FLJ43106; LAM; TSC2_HUMAN; TSC4; Tuberous sclerosis 2; Tuberous sclerosis 2 protein; Tuberous sclerosis 2 protein homolog.
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Background
Tuberin is a product of the TSC2 tumor suppressor gene and an important regulator of cell proliferation and tumor development. Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. Tuberin is directly phosphorylated at Thr1462 by Akt/PKB. Phosphorylation at Thr1462 and Tyr1571 regulates tuberin-hamartin complexes and tuberin activity.
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Research Field
Cell Biology
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Rat
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Application
IHC-P,FC,ELISA
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Dilution Ratio
IHC: 1/50-1/100 ELISA: 1/5000-1/10000
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Molecular Weight
Calculated MW: 200kDa
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Clonality
Polyclonal
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Clonality No.
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Isotype
IgG
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Immunogen
KLH conjugated Synthesised phosphopeptide derived from human Tuberin around the phosphorylation site of Thr1462
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Purification
affinity purified by Protein A
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Storage
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.