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Product Name
CBX1 Mouse mAb
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Gene ID
10951
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SwissProt ID
P83916
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Gene Name
CBX1
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Alternative Names
CBX1; CBX; Chromobox protein homolog 1; HP1Hsbeta; Heterochromatin protein 1 homolog beta; HP1 beta; Heterochromatin protein p25; M31; Modifier 1 protein; p25beta
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Background
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human
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Application
IHC-P,ICC/IF,FC
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Dilution Ratio
IHC: 1/100-1/200 IF: 1/50-1/200 FC: 1/50-1/100
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Molecular Weight
Calculated MW: 21 kDa; Observed MW: 21 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
7D8G7
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Isotype
IgG1
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Immunogen
Purified recombinant fragment of human PAX3 expressed in E. Coli.
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Purification
Ascitic Fluid
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Purified antibody in PBS with 0.05% sodium azide.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.