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Product Name
SLC25A6 Rabbit pAb
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Gene ID
293
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SwissProt ID
P12236
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Gene Name
SLC25A6
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Alternative Names
ADP/ATP translocase 3; ADP,ATP carrier protein 3; ADP,ATP carrier protein, isoform T2; ANT 2; Adenine nucleotide translocator 3; ANT 3; Solute carrier family 25 member 6; SLC25A6; ANT3; ORF Names: CDABP0051
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Background
ANT2 (adenine nucleotide translocator 2), also known as SLC25A5 (solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5), T2, T3, 2F1 or AAC2, is a 298 amino acid multi-pass membrane protein that localizes to the inner mitochondrial membrane and contains three solcar repeats. Existing as one of the most abundant mitochondrial proteins, ANT2 functions as a homodimer that facilitates the exchange of ADP and ATP between the mitochondrion and the cytosol, thus linking the compartment of ATP production (within the mitochondrion) to the areas of ATP utilization (within the cytosol). Suppression of ANT2 in breast cancer cells results in apoptosis and tumor growth inhibition, suggesting that ANT2 may be involved in carcinogenesis. ANT3 (adenine nucleotide translocator 2) is a 298 amino acid mitochondrial protein that functions in a similar manner to ANT2 but, unlike ANT2, may also play a role in the formation of the permeability transition pore complex (PTPC), a structure that is important for the regulation of apoptosis.
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Research Field
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB, IHC-P
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/200
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Molecular Weight
Calculated MW: 33kDa
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Clonality
Polyclonal Antibody
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Clonality No.
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Isotype
IgG
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Immunogen
Synthetic peptide corresponding to Human SLC25A6.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.