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Product Name
ABCG2 (2F7) Mouse mAb
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Gene ID
9429
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SwissProt ID
Q9UNQ0
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Gene Name
ABCG2
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Alternative Names
ABCG2; ABCP; BCRP; BCRP1; MXR; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; CD338
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Background
ABCG2 confers resistance for a variety of chemotherapeutic agents, including anthracyclines, mitoxantrone, bisantrene and topotecan. Play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
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Research Field
Stem Cells
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human,Mouse,Monkey
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Application
WB,IHC-P,ICC/IF,FC
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/100-1/200 IF: 1/50-1/200 FC: 1/50-1/100
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Molecular Weight
Calculated MW: 72 kDa; Observed MW: 72 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
2F7-6G2-6D4
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Isotype
IgG1
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Immunogen
Purified recombinant fragment of human ABCG2 expressed in E. Coli.
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Purification
Ascitic Fluid
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Ascitic fluid containing 0.03% sodium azide.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.