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货号:
342529
别名:
AKT1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha
应用:
WB,IHC-F,IHC-P,ICC/IF,ELISA
反应种属:
Human,Mouse,Rat
目录价格:
RMB(含税报价)
数量:
-
+
(库存
件)
查看代理商
预计货期:
现货
说明书PDF
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产品详情
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引用文献
用户反馈
产品详情
Product Name
AKT Rabbit pAb
Gene ID
207
SwissProt ID
P31749
Gene Name
AKT1
Alternative Names
AKT1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha
Background
Akt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis. This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase. Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 and by phosphorylation within the carboxy terminus at Ser473.
Research Field
Signal Transduction
Product Categories
Primary antibody
Host
Rabbit
Reactivity
Human,Mouse,Rat
Application
WB,IHC-F,IHC-P,ICC/IF,ELISA
Cited
WB (Chicken)
Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/10000
Molecular Weight
Calculated MW: 56 kDa; Observed MW: 60 kDa
Clonality
Polyclonal Antibody
Clonality No.
-
Isotype
IgG
Immunogen
The antiserum was produced against synthesized peptide derived from human AKT1/2/3.
Purification
Affinity Purified
Conjugation
Unconjugated
Modification
Unmodified
Form
Liquid
Buffer System
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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验证详情
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应用缩写
WB:
蛋白质印迹法
IHC-P:
石蜡切片样本的免疫组织化学法
IHC-F:
冰冻切片样本的免疫组织化学法
ICC/IF:
免疫细胞荧光
IP:
免疫沉淀法
FC:
流式细胞术
ChIP:
染色质免疫沉淀法
ELISA:
酶联免疫吸附测定
正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用,请参照上方的缩写含义,仔细对照后选择合适的产品。
引用文献
更多完整详情
标 题:
Establishment of a novel mesenchymal stem cell-based regimen for chronic myeloid leukemia differentiation therapy
样本种属:
Human
杂 志:
Cell Death & Disease
应用:
WB
IF:
8.469
文献链接
标 题:
Drug-free in vitro activation combined with 3D-bioprinted adipose-derived stem cells restores ovarian function of rats with premature ovarian insufficiency
样本种属:
Rat
杂 志:
Stem Cell Research & Therapy
应用:
WB
IF:
8.079
文献链接
标 题:
Osteogenic peptides in periodontal ligament stem cell-containing three-dimensional bioscaffolds promote bone healing
样本种属:
Human
杂 志:
Biomaterials Science
应用:
WB
IF:
6.843
文献链接
标 题:
CTGF facilitates cell-cell communication in chondrocytes via PI3K/Akt signalling pathway
样本种属:
Mouse
杂 志:
CELL PROLIFERATION
应用:
WB
IF:
6.831
文献链接
标 题:
FGF7-induced E11 facilitates cell-cell communication through connexin43
样本种属:
Mouse
杂 志:
International Journal of Biological Sciences
应用:
WB
IF:
6.582
文献链接
标 题:
Investigation on the mechanisms of biochanin A alleviate PM10-induced acute pulmonary cell injury
样本种属:
Human
杂 志:
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
应用:
WB
IF:
6.291
文献链接
标 题:
Theabrownin from Dark Tea Ameliorates Insulin Resistance via Attenuating Oxidative Stress and Modulating IRS-1/PI3K/Akt Pathway in HepG2 Cells
样本种属:
Human
杂 志:
Nutrients
应用:
WB
IF:
5.9
文献链接
标 题:
Melatonin protects HT-22 cells against palmitic acid-induced glucolipid metabolic dysfunction and cell injuries: Involved in the regulation of synaptic plasticity and circadian rhythms
样本种属:
Mouse
杂 志:
BIOCHEMICAL PHARMACOLOGY
应用:
WB
IF:
5.8
文献链接
标 题:
TREM2 mitigates NLRP3-mediated neuroinflammation through the NF-κB and PI3k/Akt signaling pathways in juvenile rats exposed to ambient particulate matter
样本种属:
Rat,Mouse
杂 志:
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
应用:
WB
IF:
5.8
文献链接
标 题:
CPD-002, a novel VEGFR2 inhibitor, relieves rheumatoid arthritis by reducing angiogenesis through the suppression of the VEGFR2/PI3K/AKT signaling pathway
样本种属:
Rat,Human
杂 志:
INTERNATIONAL IMMUNOPHARMACOLOGY
应用:
WB
IF:
5.6
文献链接
标 题:
MicroRNA-181b attenuates lipopolysaccharide-induced inflammatory responses in pulpitis via the PLAU/AKT/NF-κB axis
样本种属:
Human
杂 志:
INTERNATIONAL IMMUNOPHARMACOLOGY
应用:
WB
IF:
5.6
文献链接
标 题:
Valsartan attenuates LPS-induced ALI by modulating NF-κB and MAPK pathways
样本种属:
Mouse,Human
杂 志:
Frontiers in Pharmacology
应用:
WB
IF:
5.6
文献链接
标 题:
Tanshinone IIA promotes vascular normalization and boosts Sorafenib’s anti-hepatoma activity via modulating the PI3K-AKT pathway
样本种属:
Human
杂 志:
Frontiers in Pharmacology
应用:
WB
IF:
5.6
文献链接
标 题:
Dendrobium huoshanense in the treatment of ulcerative colitis: Network pharmacology and experimental validation
样本种属:
Mouse
杂 志:
JOURNAL OF ETHNOPHARMACOLOGY
应用:
WB
IF:
5.4
文献链接
标 题:
Elucidating the chemical interaction effects of herb pair Danshen-Chuanxiong and its anti-ischemic stroke activities evaluation
样本种属:
Rat
杂 志:
JOURNAL OF ETHNOPHARMACOLOGY
应用:
WB
IF:
5.4
文献链接
标 题:
Hyperglycemia effect of Pinctada martensii hydrolysate in diabetic db/db mice
样本种属:
Mouse
杂 志:
JOURNAL OF ETHNOPHARMACOLOGY
应用:
WB
IF:
5.4
文献链接
标 题:
Zhisou powder displays therapeutic effect on chronic bronchitis through inhibiting PI3K/Akt/HIF-1α/VEGFA signaling pathway and reprograming metabolic pathway of arachidonic acid
样本种属:
Rat
杂 志:
JOURNAL OF ETHNOPHARMACOLOGY
应用:
WB
IF:
5.4
文献链接
标 题:
Single-cell RNA-seq and bulk-seq identify RAB17 as a potential regulator of angiogenesis by human dermal microvascular endothelial cells in diabetic foot ulcers
样本种属:
Human,Mouse
杂 志:
Burns & Trauma
应用:
WB,IHC
IF:
5.3
文献链接
标 题:
Pterostilbene Coupled with Physical Exercise Effectively Mitigates Collagen-Induced Articular Synovial by Correcting the PI3K/Akt/NF-κB Signal Pathway
样本种属:
Rat
杂 志:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
应用:
WB
IF:
5.279
文献链接
标 题:
Acetylated xylo-oligosaccharide from Hawthorn kernels inhibits colon cancer cells in vitro and in vivo
样本种属:
Mouse,Human
杂 志:
Journal of Functional Foods
应用:
WB
IF:
5.223
文献链接
标 题:
BKM120 inhibits malignant rhabdoid tumor of the kidney through induction of apoptosis and G0/G1 phase arrest
样本种属:
Human,Mouse
杂 志:
EUROPEAN JOURNAL OF PHARMACOLOGY
应用:
WB
IF:
5.195
文献链接
标 题:
Luteolin blocks the ROS/PI3K/AKT pathway to inhibit mesothelial-mesenchymal transition and reduce abdominal adhesions
样本种属:
Human
杂 志:
EUROPEAN JOURNAL OF PHARMACOLOGY
应用:
WB
IF:
5
文献链接
标 题:
PLEK2 mediates metastasis and vascular invasion via the ubiquitin‐dependent degradation of SHIP2 in non‐small cell lung cancer
样本种属:
Human
杂 志:
INTERNATIONAL JOURNAL OF CANCER
应用:
WB,IP
IF:
4.982
文献链接
标 题:
miR-15a-5p enhances the malignant phenotypes of colorectal cancer cells through the STAT3/TWIST1 and PTEN/AKT signaling pathways by targeting SIRT4
样本种属:
Human
杂 志:
CELLULAR SIGNALLING
应用:
WB
IF:
4.85
文献链接
标 题:
Identification of TLN1 as a prognostic biomarker to effect cell proliferation and differentiation in acute myeloid leukemia
样本种属:
Human
杂 志:
BMC CANCER
应用:
WB
IF:
4.64
文献链接
标 题:
Pinellia ternata lectin induces inflammation through TLR4 receptor and mediates PI3K/Akt/mTOR axis to regulate NF-κB signaling pathway
样本种属:
Mouse
杂 志:
TOXICOLOGY
应用:
WB
IF:
4.57
文献链接
标 题:
Hsp90 Relieves Heat Stress-Induced Damage in Mouse Kidneys: Involvement of Antiapoptotic PKM2-AKT and Autophagic HIF-1α Signaling
样本种属:
Mouse
杂 志:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
应用:
WB
IF:
4.556
文献链接
标 题:
Zearalenone Induces Apoptosis and Cytoprotective Autophagy in Chicken Granulosa Cells by PI3K-AKT-mTOR and MAPK Signaling Pathways
样本种属:
Chicken
杂 志:
Toxins
应用:
WB
IF:
4.546
文献链接
标 题:
1-Monopalmitin promotes lung cancer cells apoptosis through PI3K/Akt pathway in vitro
样本种属:
Human
杂 志:
ENVIRONMENTAL TOXICOLOGY
应用:
WB
IF:
4.5
文献链接
标 题:
Protective Effects of Phytic Acid on CCl4-Induced Liver Fibrosis in Mice
样本种属:
Mouse
杂 志:
JOURNAL OF FOOD BIOCHEMISTRY
应用:
WB
IF:
4
文献链接
标 题:
Zeaxanthin impairs angiogenesis and tumor growth of glioblastoma: An in vitro and in vivo study
样本种属:
Human
杂 志:
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
应用:
WB
IF:
3.9
文献链接
标 题:
PDGF-AA promotes cell-to-cell communication in osteocytes through PI3K/Akt signaling pathway
样本种属:
Mouse
杂 志:
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
应用:
WB
IF:
3.848
文献链接
标 题:
Mechanisms and Molecular Targets of Compound Danshen Dropping Pill for Heart Disease Caused by High Altitude Based on Network Pharmacology and Molecular Docking
样本种属:
Rat,Human
杂 志:
ACS Omega
应用:
WB
IF:
3.512
文献链接
标 题:
CD5L induces inflammation and survival in RA-FLS through ERK1/2 MAPK pathway
样本种属:
Human
杂 志:
AUTOIMMUNITY
应用:
WB
IF:
3.5
文献链接
标 题:
Insulin-like growth factor 1 promotes neural differentiation of human stem cells from the apical papilla
样本种属:
Human
杂 志:
ARCHIVES OF ORAL BIOLOGY
应用:
WB
IF:
2.635
文献链接
标 题:
The virulence factor GroEL promotes gelatinase secretion from cells in the osteoblast lineage: Implication for direct crosstalk between bacteria and adult cells
样本种属:
Mouse
杂 志:
ARCHIVES OF ORAL BIOLOGY
应用:
WB
IF:
1.931
文献链接
标 题:
Design, synthesis and biological evaluation of novel FAK inhibitors with better selectivity over IR than TAE226
样本种属:
Human
杂 志:
BIOORGANIC CHEMISTRY
应用:
WB
IF:
0
文献链接
标 题:
Platelet-derived growth factor PDGF-AA upregulates connexin 43 expression and promotes gap junction formations in osteoblast cells through p-Akt signaling
样本种属:
Mouse
杂 志:
Biochemistry and Biophysics Reports
应用:
WB
IF:
0
文献链接
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