货号： 342529
别名： AKT1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha
应用： WB,IHC-F,IHC-P,ICC/IF,ELISA
反应种属： Human,Mouse,Rat
目录价格：
RMB(含税报价)
数量： - + （库存件）
查看代理商 预计货期：现货 说明书PDF
产品详情
  • Product Name
    AKT Rabbit pAb
  • Gene ID
    207
  • SwissProt ID
    P31749
  • Gene Name
    AKT1
  • Alternative Names
    AKT1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha
  • Background
    Akt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis. This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase. Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 and by phosphorylation within the carboxy terminus at Ser473.
  • Research Field
    Signal Transduction
  • Product Categories
    Primary antibody
  • Host
    Rabbit
  • Reactivity
    Human,Mouse,Rat
  • Application
    WB,IHC-F,IHC-P,ICC/IF,ELISA
  • Cited
    WB (Chicken)
  • Dilution Ratio
    WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/10000
  • Molecular Weight
    Calculated MW: 56 kDa; Observed MW: 60 kDa
  • Clonality
    Polyclonal Antibody
  • Clonality No.
    -
  • Isotype
    IgG
  • Immunogen
    The antiserum was produced against synthesized peptide derived from human AKT1/2/3.
  • Purification
    Affinity Purified
  • Conjugation
    Unconjugated
  • Modification
    Unmodified
  • Form
    Liquid
  • Buffer System
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
  • Storage
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
验证详情

应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定 正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用，请参照上方的缩写含义，仔细对照后选择合适的产品。
引用文献 更多完整详情
标 题： Establishment of a novel mesenchymal stem cell-based regimen for chronic myeloid leukemia differentiation therapy
样本种属： Human
杂 志： Cell Death & Disease
应用： WB
IF： 8.469
文献链接
标 题： Drug-free in vitro activation combined with 3D-bioprinted adipose-derived stem cells restores ovarian function of rats with premature ovarian insufficiency
样本种属： Rat
杂 志： Stem Cell Research & Therapy
应用： WB
IF： 8.079
文献链接
标 题： Osteogenic peptides in periodontal ligament stem cell-containing three-dimensional bioscaffolds promote bone healing
样本种属： Human
杂 志： Biomaterials Science
应用： WB
IF： 6.843
文献链接
标 题： CTGF facilitates cell-cell communication in chondrocytes via PI3K/Akt signalling pathway
样本种属： Mouse
杂 志： CELL PROLIFERATION
应用： WB
IF： 6.831
文献链接
标 题： FGF7-induced E11 facilitates cell-cell communication through connexin43
样本种属： Mouse
杂 志： International Journal of Biological Sciences
应用： WB
IF： 6.582
文献链接
标 题： Investigation on the mechanisms of biochanin A alleviate PM10-induced acute pulmonary cell injury
样本种属： Human
杂 志： ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
应用： WB
IF： 6.291
文献链接
标 题： Theabrownin from Dark Tea Ameliorates Insulin Resistance via Attenuating Oxidative Stress and Modulating IRS-1/PI3K/Akt Pathway in HepG2 Cells
样本种属： Human
杂 志： Nutrients
应用： WB
IF： 5.9
文献链接
标 题： Melatonin protects HT-22 cells against palmitic acid-induced glucolipid metabolic dysfunction and cell injuries: Involved in the regulation of synaptic plasticity and circadian rhythms
样本种属： Mouse
杂 志： BIOCHEMICAL PHARMACOLOGY
应用： WB
IF： 5.8
文献链接
标 题： TREM2 mitigates NLRP3-mediated neuroinflammation through the NF-κB and PI3k/Akt signaling pathways in juvenile rats exposed to ambient particulate matter
样本种属： Rat,Mouse
杂 志： ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
应用： WB
IF： 5.8
文献链接
标 题： CPD-002, a novel VEGFR2 inhibitor, relieves rheumatoid arthritis by reducing angiogenesis through the suppression of the VEGFR2/PI3K/AKT signaling pathway
样本种属： Rat,Human
杂 志： INTERNATIONAL IMMUNOPHARMACOLOGY
应用： WB
IF： 5.6
文献链接
标 题： MicroRNA-181b attenuates lipopolysaccharide-induced inflammatory responses in pulpitis via the PLAU/AKT/NF-κB axis
样本种属： Human
杂 志： INTERNATIONAL IMMUNOPHARMACOLOGY
应用： WB
IF： 5.6
文献链接
标 题： Valsartan attenuates LPS-induced ALI by modulating NF-κB and MAPK pathways
样本种属： Mouse,Human
杂 志： Frontiers in Pharmacology
应用： WB
IF： 5.6
文献链接
标 题： Tanshinone IIA promotes vascular normalization and boosts Sorafenib’s anti-hepatoma activity via modulating the PI3K-AKT pathway
样本种属： Human
杂 志： Frontiers in Pharmacology
应用： WB
IF： 5.6
文献链接
标 题： Dendrobium huoshanense in the treatment of ulcerative colitis: Network pharmacology and experimental validation
样本种属： Mouse
杂 志： JOURNAL OF ETHNOPHARMACOLOGY
应用： WB
IF： 5.4
文献链接
标 题： Elucidating the chemical interaction effects of herb pair Danshen-Chuanxiong and its anti-ischemic stroke activities evaluation
样本种属： Rat
杂 志： JOURNAL OF ETHNOPHARMACOLOGY
应用： WB
IF： 5.4
文献链接
标 题： Hyperglycemia effect of Pinctada martensii hydrolysate in diabetic db/db mice
样本种属： Mouse
杂 志： JOURNAL OF ETHNOPHARMACOLOGY
应用： WB
IF： 5.4
文献链接
标 题： Zhisou powder displays therapeutic effect on chronic bronchitis through inhibiting PI3K/Akt/HIF-1α/VEGFA signaling pathway and reprograming metabolic pathway of arachidonic acid
样本种属： Rat
杂 志： JOURNAL OF ETHNOPHARMACOLOGY
应用： WB
IF： 5.4
文献链接
标 题： Single-cell RNA-seq and bulk-seq identify RAB17 as a potential regulator of angiogenesis by human dermal microvascular endothelial cells in diabetic foot ulcers
样本种属： Human，Mouse
杂 志： Burns & Trauma
应用： WB，IHC
IF： 5.3
文献链接
标 题： Pterostilbene Coupled with Physical Exercise Effectively Mitigates Collagen-Induced Articular Synovial by Correcting the PI3K/Akt/NF-κB Signal Pathway
样本种属： Rat
杂 志： JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
应用： WB
IF： 5.279
文献链接
标 题： Acetylated xylo-oligosaccharide from Hawthorn kernels inhibits colon cancer cells in vitro and in vivo
样本种属： Mouse,Human
杂 志： Journal of Functional Foods
应用： WB
IF： 5.223
文献链接
标 题： BKM120 inhibits malignant rhabdoid tumor of the kidney through induction of apoptosis and G0/G1 phase arrest
样本种属： Human,Mouse
杂 志： EUROPEAN JOURNAL OF PHARMACOLOGY
应用： WB
IF： 5.195
文献链接
标 题： Luteolin blocks the ROS/PI3K/AKT pathway to inhibit mesothelial-mesenchymal transition and reduce abdominal adhesions
样本种属： Human
杂 志： EUROPEAN JOURNAL OF PHARMACOLOGY
应用： WB
IF： 5
文献链接
标 题： PLEK2 mediates metastasis and vascular invasion via the ubiquitin‐dependent degradation of SHIP2 in non‐small cell lung cancer
样本种属： Human
杂 志： INTERNATIONAL JOURNAL OF CANCER
应用： WB,IP
IF： 4.982
文献链接
标 题： miR-15a-5p enhances the malignant phenotypes of colorectal cancer cells through the STAT3/TWIST1 and PTEN/AKT signaling pathways by targeting SIRT4
样本种属： Human
杂 志： CELLULAR SIGNALLING
应用： WB
IF： 4.85
文献链接
标 题： Identification of TLN1 as a prognostic biomarker to effect cell proliferation and differentiation in acute myeloid leukemia
样本种属： Human
杂 志： BMC CANCER
应用： WB
IF： 4.64
文献链接
标 题： Pinellia ternata lectin induces inflammation through TLR4 receptor and mediates PI3K/Akt/mTOR axis to regulate NF-κB signaling pathway
样本种属： Mouse
杂 志： TOXICOLOGY
应用： WB
IF： 4.57
文献链接
标 题： Hsp90 Relieves Heat Stress-Induced Damage in Mouse Kidneys: Involvement of Antiapoptotic PKM2-AKT and Autophagic HIF-1α Signaling
样本种属： Mouse
杂 志： INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
应用： WB
IF： 4.556
文献链接
标 题： Zearalenone Induces Apoptosis and Cytoprotective Autophagy in Chicken Granulosa Cells by PI3K-AKT-mTOR and MAPK Signaling Pathways
样本种属： Chicken
杂 志： Toxins
应用： WB
IF： 4.546
文献链接
标 题： 1-Monopalmitin promotes lung cancer cells apoptosis through PI3K/Akt pathway in vitro
样本种属： Human
杂 志： ENVIRONMENTAL TOXICOLOGY
应用： WB
IF： 4.5
文献链接
标 题： Protective Effects of Phytic Acid on CCl4-Induced Liver Fibrosis in Mice
样本种属： Mouse
杂 志： JOURNAL OF FOOD BIOCHEMISTRY
应用： WB
IF： 4
文献链接
标 题： Zeaxanthin impairs angiogenesis and tumor growth of glioblastoma: An in vitro and in vivo study
样本种属： Human
杂 志： ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
应用： WB
IF： 3.9
文献链接
标 题： PDGF-AA promotes cell-to-cell communication in osteocytes through PI3K/Akt signaling pathway
样本种属： Mouse
杂 志： ACTA BIOCHIMICA ET BIOPHYSICA SINICA
应用： WB
IF： 3.848
文献链接
标 题： Mechanisms and Molecular Targets of Compound Danshen Dropping Pill for Heart Disease Caused by High Altitude Based on Network Pharmacology and Molecular Docking
样本种属： Rat,Human
杂 志： ACS Omega
应用： WB
IF： 3.512
文献链接
标 题： CD5L induces inflammation and survival in RA-FLS through ERK1/2 MAPK pathway
样本种属： Human
杂 志： AUTOIMMUNITY
应用： WB
IF： 3.5
文献链接
标 题： Insulin-like growth factor 1 promotes neural differentiation of human stem cells from the apical papilla
样本种属： Human
杂 志： ARCHIVES OF ORAL BIOLOGY
应用： WB
IF： 2.635
文献链接
标 题： The virulence factor GroEL promotes gelatinase secretion from cells in the osteoblast lineage: Implication for direct crosstalk between bacteria and adult cells
样本种属： Mouse
杂 志： ARCHIVES OF ORAL BIOLOGY
应用： WB
IF： 1.931
文献链接
标 题： Platelet-derived growth factor PDGF-AA upregulates connexin 43 expression and promotes gap junction formations in osteoblast cells through p-Akt signaling
样本种属： Mouse
杂 志： Biochemistry and Biophysics Reports
应用： WB
IF： 0
文献链接
标 题： Design, synthesis and biological evaluation of novel FAK inhibitors with better selectivity over IR than TAE226
样本种属： Human
杂 志： BIOORGANIC CHEMISTRY
应用： WB
IF： 0
文献链接
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