货号： 341034
别名： CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1
应用： WB,IHC-F,IHC-P,ICC/IF,ELISA
反应种属： Human,Mouse,Rat
目录价格：
RMB(含税报价)
数量： - + （库存件）
查看代理商 预计货期：现货 说明书PDF
产品详情
  • Product Name
    Cleaved-Caspase 3 p17 Rabbit pAb
  • Gene ID
    836
  • SwissProt ID
    P42574
  • Gene Name
    CASP3
  • Alternative Names
    CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1
  • Background
    Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.
  • Research Field
    Cell Biology
  • Product Categories
    Primary antibody
  • Host
    Rabbit
  • Reactivity
    Human,Mouse,Rat
  • Application
    WB,IHC-F,IHC-P,ICC/IF,ELISA
  • Cited
    WB (Pig,Chicken)
  • Dilution Ratio
    WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/10000
  • Molecular Weight
    Calculated MW: 32 kDa; Observed MW: 17 kDa
  • Clonality
    Polyclonal Antibody
  • Clonality No.
    -
  • Isotype
    IgG
  • Immunogen
    The antiserum was produced against synthesized peptide derived from human Caspase 3.
  • Purification
    Affinity Purified
  • Conjugation
    Unconjugated
  • Modification
    Cleaved
  • Form
    Liquid
  • Buffer System
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
  • Storage
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
验证详情

应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定 正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用，请参照上方的缩写含义，仔细对照后选择合适的产品。
引用文献 更多完整详情
标 题： A ferroptosis-targeting ceria anchored halloysite as orally drug delivery system for radiation colitis therapy
样本种属： Mouse
杂 志： Nature Communications
应用： WB,IHC
IF： 16.6
文献链接
标 题： Alginate self-adhesive hydrogel combined with dental pulp stem cells and FGF21 repairs hemisection spinal cord injury via apoptosis and autophagy mechanisms
样本种属： Mouse
杂 志： CHEMICAL ENGINEERING JOURNAL
应用： WB
IF： 13.273
文献链接
标 题： Jolkinolide B sensitizes bladder cancer to mTOR inhibitors via dual inhibition of Akt signaling and autophagy
样本种属： Human
杂 志： CANCER LETTERS
应用： WB
IF： 8.679
文献链接
标 题： Jolkinolide B targets thioredoxin and glutathione systems to induce ROS-mediated paraptosis and apoptosis in bladder cancer cells
样本种属： Human
杂 志： CANCER LETTERS
应用： WB
IF： 8.679
文献链接
标 题： Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond
样本种属： Human
杂 志： JOURNAL OF MEDICINAL CHEMISTRY
应用： WB
IF： 8.039
文献链接
标 题： Glucomannan from Aloe vera gel maintains intestinal barrier integrity via mitigating anoikis mediated by Nrf2-mitochondria axis
样本种属： Mouse,Rat
杂 志： INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
应用： WB
IF： 8.025
文献链接
标 题： Multifunctional Near-Infrared Dye IR-817 Encapsulated in Albumin Nanoparticles for Enhanced Imaging and Photothermal Therapy in Melanoma
样本种属： Mouse
杂 志： International Journal of Nanomedicine
应用： IHC
IF： 8
文献链接
标 题： Novel berberine derivatives as p300 histone acetyltransferase inhibitors in combination treatment for breast cancer
样本种属： Human
杂 志： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
应用： WB
IF： 6.7
文献链接
标 题： CGRP Regulates Nucleus Pulposus Cell Apoptosis and Inflammation via the MAPK/NF-κB Signaling Pathways during Intervertebral Disc Degeneration
样本种属： Human
杂 志： Oxidative Medicine and Cellular Longevity
应用： WB
IF： 6.543
文献链接
标 题： Genomic G-quadruplex folding triggers a cytokine-mediated inflammatory feedback loop to aggravate inflammatory diseases
样本种属： Rat
杂 志： iScience
应用： WB
IF： 6.11
文献链接
标 题： Nrf2 protects against acute lung injury and inflammation by modulating TLR4 and Akt signaling
样本种属： Mouse
杂 志： FREE RADICAL BIOLOGY AND MEDICINE
应用： WB
IF： 6.02
文献链接
标 题： Catalpol as a Component of Rehmannia glutinosa Protects Spinal Cord Injury by Inhibiting Endoplasmic Reticulum Stress-Mediated Neuronal Apoptosis
样本种属： Rat
杂 志： Frontiers in Pharmacology
应用： WB
IF： 5.988
文献链接
标 题： Network Pharmacology-Based Investigation and Experimental Exploration of the Antiapoptotic Mechanism of Colchicine on Myocardial Ischemia Reperfusion Injury.
样本种属： Rat
杂 志： Frontiers in Pharmacology
应用： WB
IF： 5.811
文献链接
标 题： ZWZ-3, a Fluorescent Probe Targeting Mitochondria for Melanoma Imaging and Therapy.
样本种属： Mouse
杂 志： Frontiers in Pharmacology
应用： WB
IF： 5.811
文献链接
标 题： Downregulation of MAL2 inhibits breast cancer progression through regulating β-catenin/c-Myc axis
样本种属： Human
杂 志： Cancer Cell International
应用： WB
IF： 5.8
文献链接
标 题： Engineered macrophage-derived cellular vesicles for NIR-II fluorescence imaging-guided precise cancer photo-immunotherapy
样本种属： Mouse
杂 志： COLLOIDS AND SURFACES B-BIOINTERFACES
应用： WB
IF： 5.8
文献链接
标 题： Structural insight into ASH1L PHD finger recognizing methylated histone H3K4 and promoting cell growth in prostate cancer.
样本种属： Human
杂 志： Frontiers in Oncology
应用： WB
IF： 5.738
文献链接
标 题： The HIF-1/ BNIP3 pathway mediates mitophagy to inhibit the pyroptosis of fibroblast-like synoviocytes in rheumatoid arthritis
样本种属： Human
杂 志： INTERNATIONAL IMMUNOPHARMACOLOGY
应用： WB
IF： 5.6
文献链接
标 题： The mmu_circ_003062, hsa_circ_0075663/miR-490-3p/CACNA1H axis mediates apoptosis in renal tubular cells in association with endoplasmic reticulum stress following ischemic acute kidney injury
样本种属： Mouse,Human
杂 志： INTERNATIONAL IMMUNOPHARMACOLOGY
应用： WB
IF： 5.6
文献链接
标 题： Traditional Chinese Medicine formula Wubi Shanyao Pills protects against reproductive aging by activating SIRT1/3 to reduce apoptosis
样本种属： Mouse
杂 志： JOURNAL OF ETHNOPHARMACOLOGY
应用： IHC
IF： 5.4
文献链接
标 题： Elucidating the chemical interaction effects of herb pair Danshen-Chuanxiong and its anti-ischemic stroke activities evaluation
样本种属： Rat
杂 志： JOURNAL OF ETHNOPHARMACOLOGY
应用： WB
IF： 5.4
文献链接
标 题： SKLB-14b, a novel oral microtubule-destabilizing agent based on hydroxamic acid with potent anti-tumor and anti-multidrug resistance activities
样本种属： Human
杂 志： BIOORGANIC CHEMISTRY
应用： WB
IF： 5.307
文献链接
标 题： Nanostructured lipid carriers loaded with morellic acid for enhanced anticancer efficacy: preparation, characterization, pharmacokinetics and anticancer evaluation
样本种属： Mouse,Human
杂 志： American Journal of Cancer Research
应用： WB
IF： 5.3
文献链接
标 题： Mitochondrion-Targeted NIR Therapeutic Agent Suppresses Melanoma by Inducing Apoptosis and Cell Cycle Arrest via E2F/Cyclin/CDK Pathway
样本种属： Mouse
杂 志： Pharmaceuticals
应用： WB
IF： 5.2
文献链接
标 题： Synthesis and biological evaluation of lycoctonine derivatives with cardiotonic and calcium channels inhibitory activities
样本种属： Rat
杂 志： BIOORGANIC CHEMISTRY
应用： WB
IF： 5.1
文献链接
标 题： Dopamine receptor-mediated roles on retinal ganglion cell hyperexcitability and injury in experimental glaucoma
样本种属： Rat
杂 志： CELLULAR SIGNALLING
应用： WB
IF： 4.8
文献链接
标 题： Gga-miR-3525 Targets PDLIM3 through the MAPK Signaling Pathway to Regulate the Proliferation and Differentiation of Skeletal Muscle Satellite Cells
样本种属： Chicken
杂 志： INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
应用： WB
IF： 4.556
文献链接
标 题： Hsp90 Relieves Heat Stress-Induced Damage in Mouse Kidneys: Involvement of Antiapoptotic PKM2-AKT and Autophagic HIF-1α Signaling
样本种属： Mouse
杂 志： INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
应用： WB
IF： 4.556
文献链接
标 题： Zearalenone Induces Apoptosis and Cytoprotective Autophagy in Chicken Granulosa Cells by PI3K-AKT-mTOR and MAPK Signaling Pathways
样本种属： Chicken
杂 志： Toxins
应用： WB
IF： 4.546
文献链接
标 题： Saponins of Marsdenia Tenacissima promotes apoptosis of hepatocellular carcinoma cells through damaging mitochondria then activating cytochrome C/Caspase-9/Caspase-3 pathway
样本种属： Human
杂 志： Journal of Cancer
应用： WB
IF： 4.478
文献链接
标 题： Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways
样本种属： Mouse
杂 志： EUROPEAN JOURNAL OF PHARMACOLOGY
应用： WB
IF： 4.432
文献链接
标 题： Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway
样本种属： Rat
杂 志： MOLECULES
应用： WB,IHC
IF： 4.412
文献链接
标 题： Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia
样本种属： Rat
杂 志： NEUROCHEMICAL RESEARCH
应用： IF
IF： 4.4
文献链接
标 题： Long-term copper exposure promotes apoptosis and autophagy by inducing oxidative stress in pig testis
样本种属： Pig
杂 志： ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
应用： WB
IF： 4.223
文献链接
标 题： Exposure to copper activates mitophagy and endoplasmic reticulum stress-mediated apoptosis in chicken (Gallus gallus) cerebrum
样本种属： Chicken
杂 志： ENVIRONMENTAL TOXICOLOGY
应用： WB
IF： 4.109
文献链接
标 题： MicroRNA-21-5p agomir inhibits apoptosis of oligodendrocyte precursor cell and attenuates white matter injury in neonatal rats
样本种属： Rat
杂 志： BRAIN RESEARCH BULLETIN
应用： IF
IF： 3.715
文献链接
标 题： Hypoxic preconditioning improves the survival and pro-angiogenic capacity of transplanted human umbilical cord mesenchymal stem cells via HIF-1α signaling in a rat model of bronchopulmonary dysplasia
样本种属： Rat
杂 志： BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
应用： WB
IF： 3.575
文献链接
标 题： Atg3 Overexpression Enhances Bortezomib-Induced Cell Death in SKM-1 Cell
样本种属： Human
杂 志： PLoS One
应用： WB
IF： 3.057
文献链接
标 题： Molecular design and anti‑melanoma activity of a novel bullfrog antibacterial peptide RGD‑chimera
样本种属： Mouse
杂 志： Oncology Letters
应用： IHC
IF： 2.311
文献链接
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