货号： 381958
别名： Phospholipid hydroperoxide glutathione peroxidase; mitochondrial; PHGPx; EC 1.11.1.12; Glutathione peroxidase 4; GPx-4; GSHPx-4
应用： WB,IHC-F,IHC-P,ICC/IF
反应种属： Human,Mouse,Rat
目录价格：
RMB(含税报价)
数量： - + （库存件）
查看代理商 预计货期：现货 说明书PDF
产品详情
  • Product Name
    Glutathione Peroxidase 4 Rabbit pAb
  • Gene ID
    2879
  • SwissProt ID
    P36969
  • Gene Name
    GPX4
  • Alternative Names
    Phospholipid hydroperoxide glutathione peroxidase; mitochondrial; PHGPx; EC 1.11.1.12; Glutathione peroxidase 4; GPx-4; GSHPx-4
  • Background
    Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage.
  • Research Field
    Signal Transduction
  • Product Categories
    Primary antibody
  • Host
    Rabbit
  • Reactivity
    Human,Mouse,Rat
  • Application
    WB,IHC-F,IHC-P,ICC/IF
  • Dilution Ratio
    WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
  • Molecular Weight
    Calculated MW: 22 kDa; Observed MW: 17 kDa
  • Clonality
    Polyclonal Antibody
  • Clonality No.
    -
  • Isotype
    IgG
  • Immunogen
    A synthesized peptide derived from human GPX4
  • Purification
    Affinity Chromatography
  • Conjugation
    Unconjugated
  • Modification
    Unmodified
  • Form
    Liquid
  • Buffer System
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
验证详情

应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定 正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用，请参照上方的缩写含义，仔细对照后选择合适的产品。
引用文献 更多完整详情
标 题： Oxoeicosanoid receptor inhibition alleviates acute myocardial infarction through activation of BCAT1
样本种属： Mouse
杂 志： BASIC RESEARCH IN CARDIOLOGY
应用： IHC
IF： 17.165
文献链接
标 题： Click chemistry-conjugated protein-drug micelles with anti-ferroptotic and anti-inflammatory properties promote regeneration in spinal cord injury
样本种属： Mouse
杂 志： CHEMICAL ENGINEERING JOURNAL
应用： WB
IF： 13.273
文献链接
标 题： Molecular mechanism of interleukin-17A regulating airway epithelial cell ferroptosis based on allergic asthma airway inflammation
样本种属： Human
杂 志： Redox Biology
应用： WB
IF： 11.4
文献链接
标 题： Circular RNA FEACR inhibits ferroptosis and alleviates myocardial ischemia/reperfusion injury by interacting with NAMPT
样本种属： Mouse
杂 志： JOURNAL OF BIOMEDICAL SCIENCE
应用： WB
IF： 11
文献链接
标 题： Di-(2-ethylhexyl) phthalate exposure leads to ferroptosis via the HIF-1α/HO-1 signaling pathway in mouse testes
样本种属： Mouse
杂 志： JOURNAL OF HAZARDOUS MATERIALS
应用： WB
IF： 10.588
文献链接
标 题： Multi-Enzyme Cascade-Triggered Nitric Oxide Release Nanoplatform Combined with Chemo Starvation-like Therapy for Multidrug-Resistant Cancers
样本种属： Mouse
杂 志： ACS Applied Materials & Interfaces
应用： WB
IF： 9.5
文献链接
标 题： Synergism of non-thermal plasma and low concentration RSL3 triggers ferroptosis via promoting xCT lysosomal degradation through ROS/AMPK/mTOR axis in lung cancer cells
样本种属： Human
杂 志： Cell Communication and Signaling
应用： WB
IF： 8.4
文献链接
标 题： Xiaojianzhong decoction attenuates gastric mucosal injury by activating the p62/Keap1/Nrf2 signaling pathway to inhibit ferroptosis
样本种属： Mouse
杂 志： BIOMEDICINE & PHARMACOTHERAPY
应用： WB
IF： 7.42
文献链接
标 题： Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2/FSP1/ROS pathway
样本种属： Mouse，Human
杂 志： FREE RADICAL BIOLOGY AND MEDICINE
应用： IHC
IF： 7.4
文献链接
标 题： Tenuifolin in the prevention of Alzheimer's disease-like phenotypes: Investigation of the mechanisms from the perspectives of calpain system, ferroptosis, and apoptosis
样本种属： Mouse
杂 志： PHYTOTHERAPY RESEARCH
应用： WB
IF： 7.2
文献链接
标 题： Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF-1α/SLC7A11 pathway
样本种属： Mouse
杂 志： CELL PROLIFERATION
应用： IHC
IF： 6.831
文献链接
标 题： 13-oxyingenol dodecanoate derivatives induce mitophagy and ferroptosis through targeting TMBIM6 as potential anti-NSCLC agents
样本种属： Human
杂 志： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
应用： WB,IF
IF： 6.7
文献链接
标 题： Bioinformatics analysis of ferroptosis-related gene AKR1C3 as a potential biomarker of asthma and its identification in BEAS-2B cells
样本种属： Human
杂 志： COMPUTERS IN BIOLOGY AND MEDICINE
应用： WB
IF： 6.698
文献链接
标 题： Wogonoside attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis through SOCS1/P53/SLC7A11 pathway
样本种属： Rat
杂 志： PHYTOTHERAPY RESEARCH
应用： IF
IF： 6.388
文献链接
标 题： Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2
样本种属： Mouse
杂 志： Antioxidants
应用： WB
IF： 6.313
文献链接
标 题： Tanshinone IIA confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis and apoptosis via VDAC1
样本种属： Rat
杂 志： INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
应用： WB
IF： 5.4
文献链接
标 题： QiShenYiQi dripping pill alleviates myocardial ischemia-induced ferroptosis via improving mitochondrial dynamical homeostasis and biogenesis
样本种属： Mouse，Rat
杂 志： JOURNAL OF ETHNOPHARMACOLOGY
应用： WB
IF： 5.195
文献链接
标 题： Hesperidin mitigates oxidative stress-induced ferroptosis in nucleus pulposus cells via Nrf2/NF-κB axis to protect intervertebral disc from degeneration
样本种属： Human
杂 志： CELL CYCLE
应用： WB
IF： 5.173
文献链接
标 题： Inhibition of cisplatin-induced Acsl4-mediated ferroptosis alleviated ovarian injury
样本种属： Mouse
杂 志： CHEMICO-BIOLOGICAL INTERACTIONS
应用： WB,IHC
IF： 5.1
文献链接
标 题： Resveratrol protects cardiomyocytes against ischemia/reperfusion-induced ferroptosis via inhibition of the VDAC1/GPX4 pathway
样本种属： Rat
杂 志： EUROPEAN JOURNAL OF PHARMACOLOGY
应用： CoIP,WB
IF： 5
文献链接
标 题： Transplantation of Human Umbilical Cord Mesenchymal Stem Cells-Derived Neural Stem Cells Pretreated with Neuregulin1&beta|| Ameliorate Cerebral Ischemic Reperfusion Injury in Rats
样本种属： Rat
杂 志： Biomolecules
应用： WB
IF： 4.879
文献链接
标 题： Identification and validation of ferroptosis-related genes for diabetic retinopathy
样本种属： Human
杂 志： CELLULAR SIGNALLING
应用： WB
IF： 4.8
文献链接
标 题： Damage to the myogenic differentiation of C2C12 cells by heat stress is associated with up-regulation of several selenoproteins
样本种属： Mouse
杂 志： Scientific Reports
应用： WB
IF： 4.122
文献链接
标 题： Hemin enhances radiosensitivity of lung cancer cells through ferroptosis
样本种属： Human
杂 志： EXPERIMENTAL CELL RESEARCH
应用： WB
IF： 3.905
文献链接
标 题： MiR-15b-3p weakens bicalutamide sensitivity in prostate cancer via targeting KLF2 to suppress ferroptosis
样本种属： Mouse,Human
杂 志： Journal of Cancer
应用： WB
IF： 3.9
文献链接
标 题： The anti-atherosclerotic effect of Paeonol against the lipid accumulation in macrophage-derived foam cells by inhibiting ferroptosis via the SIRT1/NRF2/GPX4 signaling pathway
样本种属： Mouse
杂 志： BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
应用： WB
IF： 3.1
文献链接
标 题： Inhibition of STEAP1 ameliorates inflammation and ferroptosis of acute lung injury caused by sepsis in LPS-induced human pulmonary microvascular endothelial cells
样本种属： Human
杂 志： MOLECULAR BIOLOGY REPORTS
应用： WB,IF
IF： 2.742
文献链接
标 题： Role of dysregulated ferroptosis‑related genes in cardiomyocyte ischemia‑reperfusion injury: Experimental verification and bioinformatics analysis
样本种属： Rat
杂 志： Experimental and Therapeutic Medicine
应用： WB
IF： 2.7
文献链接
标 题： Exploring the molecular biology of ischemic cardiomyopathy based on ferroptosis‑related genes
样本种属： Rat
杂 志： Experimental and Therapeutic Medicine
应用： WB
IF： 2.7
文献链接
标 题： Novel Chalcone-Phenazine Hybrids Induced Ferroptosis in U87-MG Cells through Activating Ferritinophagy
样本种属： Human
杂 志： CHEMISTRY & BIODIVERSITY
应用： WB
IF： 2.7
文献链接
标 题： The role of ferroptosis in chronic intermittent hypoxia-induced cognitive impairment
样本种属： Rat
杂 志： Sleep and Breathing
应用： WB
IF： 2.66
文献链接
标 题： PPARγ activation suppresses chondrocyte ferroptosis through mitophagy in osteoarthritis
样本种属： Rat
杂 志： Journal of Orthopaedic Surgery and Research
应用： WB，IF
IF： 2.6
文献链接
标 题： Identification and Validation of Ferroptosis-Related Biomarkers in Septic Cardiomyopathy via Bioinformatics Analysis.
样本种属： Mouse
杂 志： Frontiers in Genetics
应用： WB
IF： 0
文献链接
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