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Product Name
Cyclin H (1A7) Mouse mAb
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Gene ID
902
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SwissProt ID
P51946
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Gene Name
CCNH
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Alternative Names
CCNH; Cyclin-H; MO15-associated protein; p34; p37
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Background
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
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Research Field
Cell Biology
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human,Mouse
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Application
WB
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 38 kDa; Observed MW: 38 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
1A7-B5-D4
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Isotype
IgG2b
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Immunogen
Purified recombinant human Cyclin H protein fragments expressed in E.coli.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.