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货号： 222838

别名： APCL

应用： IHC-P,ICC/IF,FC,ELISA

反应种属： Human

目录价格：

RMB(含税报价)

数量： - + （库存件）

查看代理商预计货期：3-4个工作日说明书PDF

产品详情

Product Name

APC2 Mouse mAb
Gene ID

10297
SwissProt ID

O95996
Gene Name

APC2
Alternative Names

APCL
Background

This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms.
Research Field

-
Product Categories

Primary antibody
Host

Mouse
Reactivity

Human
Application

IHC-P,ICC/IF,FC,ELISA
Dilution Ratio

IHC: 1/100-1/200 IF: 1/50-1/200 FC: 1/50-1/100 ELISA: 1/10000
Molecular Weight

-
Clonality

Monoclonal Antibody
Clonality No.

4Z2-R6-Q6
Isotype

Mouse IgG1
Immunogen

Purified recombinant fragment of human APC2 expressed in E. Coli.
Purification

Affinity Purified
Conjugation

Unconjugated
Modification

Unmodified
Form

Liquid
Buffer System

Purified antibody in PBS with 0.05% sodium azide
Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

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验证详情

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应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用，请参照上方的缩写含义，仔细对照后选择合适的产品。

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