货号: 250229
别名: SMAD2; MADH2; MADR2; MAD homolog 2; M hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2;SMAD3; MADH3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3;smad2/3;smad2+3
应用: WB,IHC-P
反应种属: Human,Rat,Mouse
目录价格:
RMB(含税报价)
数量: - + (库存件)
查看代理商 预计货期:现货 说明书PDF
产品详情
  • Product Name
    Smad2/3 (6F7) Mouse mAb
  • Gene ID
    4087/4088
  • SwissProt ID
    P84022/Q15796
  • Gene Name
    SMAD3/SMAD2
  • Alternative Names
    SMAD2; MADH2; MADR2; MAD homolog 2; M hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2;SMAD3; MADH3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3;smad2/3;smad2+3
  • Background
    Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmit TGF-β signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5, and 8; the common-mediator Smad (co-Smad), Smad4; and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7 . Activated type I receptors associate with specific R-Smads and phosphorylate them on a conserved carboxy terminal SSXS motif. The phosphorylated R-Smad dissociates from the receptor and forms a heteromeric complex with the co-Smad (Smad4), allowing translocation of the complex to the nucleus. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses .
  • Research Field
    Signal Transduction
  • Product Categories
    Primary antibody
  • Host
    Mouse
  • Reactivity
    Human,Rat,Mouse
  • Application
    WB,IHC-P
  • Dilution Ratio
    WB: 1/500-1/1000 IHC: 1/50-1/100
  • Molecular Weight
    Calculated MW: 52 kDa; Observed MW: 52,60 kDa
  • Clonality
    Monoclonal Antibody
  • Clonality No.
    -
  • Isotype
    IgG
  • Immunogen
    Recombinant Protein of Smad3
  • Purification
    Affinity Purified
  • Conjugation
    Unconjugated
  • Modification
    Unmodified
  • Form
    Liquid
  • Buffer System
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
  • Storage
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
验证详情

应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定 正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用,请参照上方的缩写含义,仔细对照后选择合适的产品。
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