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货号： 222696

别名： CD254; ODF; OPGL; sOdf; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2

应用： WB,IHC-P,ICC/IF,FC,ELISA

反应种属： Human,Monkey

目录价格：

RMB(含税报价)

数量： - + （库存件）

查看代理商预计货期：3-4个工作日说明书PDF

产品详情

Product Name

RANKL Mouse mAb
Gene ID

8600
SwissProt ID

O14788
Gene Name

TNFSF11
Alternative Names

CD254; ODF; OPGL; sOdf; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2
Background

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Research Field

Immunology
Product Categories

Primary antibody
Host

Mouse
Reactivity

Human,Monkey
Application

WB,IHC-P,ICC/IF,FC,ELISA
Dilution Ratio

WB: 1/500-1/1000 IHC: 1/100-1/200 IF: 1/50-1/200 FC: 1/50-1/100 ELISA: 1/10000
Molecular Weight

Calculated MW: 35 kDa
Clonality

Monoclonal Antibody
Clonality No.

6I6-V2-J6
Isotype

Mouse IgG1
Immunogen

Purified recombinant fragment of human TNFSF11 expressed in E. Coli.
Purification

Affinity Purified
Conjugation

Unconjugated
Modification

Unmodified
Form

Liquid
Buffer System

Purified antibody in PBS with 0.05% sodium azide
Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

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应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用，请参照上方的缩写含义，仔细对照后选择合适的产品。

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