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Product Name
SNAI1 Mouse mAb
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Gene ID
6615
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SwissProt ID
O95863
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Gene Name
SNAI1
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Alternative Names
SNA; SNAH; SLUGH2; dJ710H13.1; SNAI1
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Background
Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human
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Application
WB,ELISA
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Dilution Ratio
WB: 1/500-1/1000 ELISA: 1/10000
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Molecular Weight
Calculated MW: 29 kDa;Observed MW: 29 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
6G7-G3-N3
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Isotype
Mouse IgG1
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Immunogen
Purified recombinant fragment of human SNAI1 expressed in E. Coli.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Ascitic fluid containing 0.03% sodium azide.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.