货号: 222613
别名: IRIS; PSCP; BRCAI; BRCC1; PNCA4; RNF53; BROVCA1; PPP1R53
应用: IHC-P,ELISA
反应种属: Human
目录价格:
RMB(含税报价)
数量: - + (库存件)
查看代理商 预计货期:3-4个工作日 说明书PDF
产品详情
  • Product Name
    BRCA1 Mouse mAb
  • Gene ID
    672
  • SwissProt ID
    P38398
  • Gene Name
    BRCA1
  • Alternative Names
    IRIS; PSCP; BRCAI; BRCC1; PNCA4; RNF53; BROVCA1; PPP1R53
  • Background
    This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
  • Research Field
    Epigenetics and Nuclear Signaling
  • Product Categories
    Primary antibody
  • Host
    Mouse
  • Reactivity
    Human
  • Application
    IHC-P,ELISA
  • Dilution Ratio
    IHC: 1/100-1/200 ELISA: 1/10000
  • Molecular Weight
    -
  • Clonality
    Monoclonal Antibody
  • Clonality No.
    1E5-Z7-U9
  • Isotype
    Mouse IgG1
  • Immunogen
    Purified recombinant fragment of human BRCA1 expressed in E. Coli.
  • Purification
    Affinity Purified
  • Conjugation
    Unconjugated
  • Modification
    Unmodified
  • Form
    Liquid
  • Buffer System
    Purified antibody in PBS with 0.05% sodium azide
  • Storage
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
验证详情

应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定 正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用,请参照上方的缩写含义,仔细对照后选择合适的产品。
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