-
Product Name
AMPK alpha 2 Mouse mAb
-
Gene ID
5563
-
SwissProt ID
P54646
-
Gene Name
PRKAA2
-
Alternative Names
AMPK; AMPK2; PRKAA; AMPKa2
-
Background
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
-
Research Field
Neuroscience
-
Product Categories
Primary antibody
-
Host
Mouse
-
Reactivity
Human,Monkey
-
Application
WB,IHC-P,FC,ELISA
-
Dilution Ratio
WB: 1/500-1/1000 IHC: 1/100-1/200 FC: 1/50-1/100 ELISA: 1/10000
-
Molecular Weight
Calculated MW: 62 kDa;Observed MW: 62 kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
1H6-G4-M3
-
Isotype
Mouse IgG1
-
Immunogen
Purified recombinant fragment of human PRKAA2 expressed in E. Coli.
-
Purification
Affinity Purified
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
Purified antibody in PBS with 0.05% sodium azide
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.