货号： 222026
别名： AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA
应用： WB,ICC/IF,FC,ELISA
反应种属： Human,Rat,Mouse,Monkey
目录价格：
RMB(含税报价)
数量： - + （库存件）
查看代理商 预计货期：3-4个工作日 说明书PDF
产品详情
  • Product Name
    AKT1 Mouse mAb
  • Gene ID
    207
  • SwissProt ID
    P31749
  • Gene Name
    AKT1
  • Alternative Names
    AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA
  • Background
    The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
  • Research Field
    Neuroscience
  • Product Categories
    Primary antibody
  • Host
    Mouse
  • Reactivity
    Human,Rat,Mouse,Monkey
  • Application
    WB,ICC/IF,FC,ELISA
  • Dilution Ratio
    WB: 1/500-1/1000 IF: 1/50-1/200 FC: 1/50-1/100 ELISA: 1/10000
  • Molecular Weight
    Calculated MW: 56 kDa;Observed MW: 56 kDa
  • Clonality
    Monoclonal Antibody
  • Clonality No.
    6J8-X4-W5
  • Isotype
    Mouse IgG1
  • Immunogen
    Purified recombinant fragment of human AKT1 expressed in E. Coli.
  • Purification
    Affinity Purified
  • Conjugation
    Unconjugated
  • Modification
    Unmodified
  • Form
    Liquid
  • Buffer System
    Purified antibody in PBS with 0.05% sodium azide
  • Storage
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
验证详情

应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定 正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用，请参照上方的缩写含义，仔细对照后选择合适的产品。
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