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Product Name
ABCG2 Mouse mAb
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Gene ID
9429
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SwissProt ID
Q9UNQ0
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Gene Name
ABCG2
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Alternative Names
MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; BCRP1; CD338; CDw338; EST157481; MGC102821
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Background
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.Tissue specificity: Highly expressed in placenta. Low expression in small intestine, liver and colon.
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Research Field
Stem Cells
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human,Mouse,Monkey
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Application
WB,ICC/IF,ELISA
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Dilution Ratio
WB: 1/500-1/1000 IF: 1/50-1/200 ELISA: 1/10000
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Molecular Weight
Calculated MW: 72 kDa;Observed MW: 50-70 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
8G5-M8-Q3
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Isotype
Mouse IgG1
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Immunogen
Purified recombinant fragment of human ABCG2 expressed in E. Coli.
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Ascitic fluid containing 0.03% sodium azide.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.