-
Product Name
TRIM5 Mouse mAb
-
Gene ID
85363
-
SwissProt ID
Q9C035
-
Gene Name
TRIM5
-
Alternative Names
RNF88; TRIM5
-
Background
TRIM5-alpha is a protein that is found in the cells of many mammals and fends of various retrovirus infections. It protects monkeys from infection with HIV-1, and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5 alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.
-
Research Field
Epigenetics and Nuclear Signaling
-
Product Categories
Primary antibody
-
Host
Mouse
-
Reactivity
Human
-
Application
WB,IHC-P
-
Dilution Ratio
WB: 1/500-1/1000 IHC: 1/100-1/200
-
Molecular Weight
Calculated MW: 56 kDa; Observed MW: 56 kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
3B11H2
-
Isotype
IgG1
-
Immunogen
Purified recombinant fragment of human trim5 alpha expressed in E. Coli.
-
Purification
Ascitic Fluid
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
Ascitic fluid containing 0.03% sodium azide.
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.