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Product Name
β-Catenin(E53K Mutant) Mouse mAb
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SwissProt ID
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Gene Name
CTNNB1, CTNNB
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Alternative Names
CTNNB1, CTNNB
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Background
Beta-catenin (or β-catenin) is a protein that in humans is encoded by the CTNNB1 gene. β-catenin is a subunit of the cadherin protein complex and also acts as an intracellular signal transducer in the Wnt signaling pathway. Deregulation of beta-catenin signaling is an important event in the genesis of a number of malignancies, such as colon cancer, melanoma, hepatocellular carcinoma, ovarian cancer, endometrial cancer, medulloblastoma pilomatricomas, and prostate cancer.
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Research Field
Signal Transduction
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Vertebrates
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Application
WB, IHC-P, ICC/IF, ELISA
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Dilution Ratio
ELISA: 1/1000-1/5000 WB: 1/500-1/2000 IHC-P: 1/50-1/100
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Clonality
Monoclonal Antibody
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Clonality No.
2P5-A8-S4
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Isotype
IgG
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Immunogen
A synthetic peptide from the internal region of β-catenin which includes the mutation of E53K, human origin.
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Purification
Purified from ascites
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
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Storage
Store at -20°C. Avoid repeated freezing and thawing