-
Product Name
Ras(A146V Mutant) Mouse mAb
-
SwissProt ID
-
Gene Name
H-Ras, K-Ras, N-Ras
-
Alternative Names
H-Ras, K-Ras, N-Ras
-
Background
The A146V mutation of KRas results in an amino acid substitution at position 146, from an alanine to a threonine. KRAS encodes a protein that is a member of the small GTPase superfamily. Ras A146V mutation results in decreased GTPase activity and constitutive signaling. It can be found in many tumors, such as lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma.
-
Research Field
Cell Biology
-
Product Categories
Primary antibody
-
Host
Mouse
-
Reactivity
Vertebrates
-
Application
WB, IHC-P,ELISA
-
Dilution Ratio
ELISA: 1/1000-1/5000 WB: 1/500-1/1000 IHC-P: 1/50-1/100
-
Clonality
Monoclonal Antibody
-
Clonality No.
1X6-S2-T2
-
Isotype
IgG
-
Immunogen
A synthetic peptide from the internal region of Ras which includes the mutation of A146V, human origin.
-
Purification
Purified from ascites
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
-
Storage
Store at -20°C. Avoid repeated freezing and thawing