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Product Name
ATM(F858L Mutant) Mouse mAb
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SwissProt ID
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Gene Name
ATM
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Alternative Names
ATM
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Background
Ataxia telangiectasia mutated (ATM) is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis. Activity of ATM protein is under tight control, and mutation of ATM can cause disease such as Ataxia telangiectasia (AT) and cancers.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Vertebrates
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Application
WB, IHC-P,ELISA
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Dilution Ratio
ELISA: 1/1000-1/5000,WB: 1/100-1/1000,IHC-P: 1/50-1/500
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Clonality
Monoclonal Antibody
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Clonality No.
3N1-N8-M7
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Isotype
IgG
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Immunogen
A synthetic peptide from the internal region of ATM which includes the mutation of F858L, human origin.
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Purification
Purified from ascites
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
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Storage
Store at -20°C. Avoid repeated freezing and thawing