产品详情
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Product Name
PDCD4 Mouse mAb
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Gene ID
27250
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SwissProt ID
Q53EL6
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Gene Name
PDCD4
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Alternative Names
Protein 197/15a, H731
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Background
PDCD4 was a suppressor of neoplastic transformation. It interacts with eukaryotic initiation factors eIF4AI and eIF4AII. PDCD4 colocalizes with eIF4A in the cytoplasm and inhibits the activity of eIF4A as an ATP-dependent RNA helicase. PDCD4 inhibits cap-dependent translation. Upon stimulation by mitogens, PDCD4 is phosphorylated on Ser67 by S6K1 kinase and then degraded through the ubiquitin pathway leading to enhanced translation and cell growth.
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Research Field
Cell Biology
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human
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Application
WB,IHC-P,ICC/IF
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Dilution Ratio
WB:1/500-1/1000,IHC-P:1/50-1/100,ICC/IF:1/50
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Molecular Weight
Calculated MW: 52 kDa; Observed MW:56 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
9T7-M7-I9
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Isotype
IgG1/kappa
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Immunogen
Peptide
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Purification
Protein A
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS, Glycerol and BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
应用缩写
WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定
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