货号： 660090
别名： DF1, DACA-1, C20orf21
应用： WB
反应种属： Human
目录价格：
RMB(含税报价)
数量： - + （库存件）
查看代理商 预计货期：3-4个工作日 说明书PDF
产品详情
  • Product Name
    YTHDF1 Mouse mAb
  • Gene ID
    54915
  • SwissProt ID
    Q9BYJ9
  • Gene Name
    YTHDF1
  • Alternative Names
    DF1, DACA-1, C20orf21
  • Background
    Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs. Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts. Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells. In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation. Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation.
  • Research Field
    Cell Biology
  • Product Categories
    Primary antibody
  • Host
    Mouse
  • Reactivity
    Human
  • Application
    WB
  • Dilution Ratio
    WB：1/500-1/1000
  • Molecular Weight
    Calculated MW: 61 kDa; Observed MW:68-70 kDa
  • Clonality
    Monoclonal Antibody
  • Clonality No.
    5C3-Y4-X7
  • Isotype
    IgG1/Kappa
  • Immunogen
    Peptide
  • Purification
    Protein G
  • Conjugation
    Unconjugated
  • Modification
    Unmodified
  • Form
    Liquid
  • Buffer System
    Liquid in PBS, Glycerol and BSA
  • Storage
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
验证详情

应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定 正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用，请参照上方的缩写含义，仔细对照后选择合适的产品。
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