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Product Name
SARS CoV/SARS CoV 2 Spike Human mAb
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Gene ID
43740568
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SwissProt ID
P0DTC2
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Gene Name
S
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Alternative Names
SARS CoV 2 Spike; Peplomer protein; E2
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Background
Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 and CLEC4M/DC-SIGNR receptors and internalization of the virus into the endosomes of the host cell induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.UniRule annotation2 Publications Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.UniRule annotation Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.UniRule annotation1 Publication
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Research Field
Infectious Diseases
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Product Categories
Primary antibody
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Host
Humanized
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Reactivity
Virus
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Application
WB
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 141 kDa; Observed MW: 141 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
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Isotype
IgG
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Immunogen
A synthesized peptide derived from SARS CoV/SARS CoV 2 Spike
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
0.01M PBS, pH 7.2
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Storage
Store at 4°C for at least 6 months. Avoid freeze/thaw cycles