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Product Name
Butyryl-Histone H2B (Lys5) Rabbit pAb
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Gene ID
－
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SwissProt ID
P62807
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Gene Name
H2BC4
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Alternative Names
H2BK5bu, Histone H2B.1 A；Histone H2B.a (H2B/a)；Histone H2B.g (H2B/g)；Histone H2B.h (H2B/h)；Histone H2B.k (H2B/k)；Histone H2B.l (H2B/l)
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Background
Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. Butyrylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. Lysine butyrylation is highly conserved in eukaryotic cells from worm to human. The unique structure and genomic localization of histone lysine butyrylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Specifically, in both human somatic and rabbit male germ cell genomes, histone butyrylation marks either active promoters or potential enhancers. Butyrylation of histone H3 at Lys18 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Mouse,Rat
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Application
WB,IHC-P
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Dilution Ratio
WB：1/500-1/1000 IHC-P：1/50-1/100
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Molecular Weight
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Clonality
Polyclonal Antibody
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Clonality No.
-
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Isotype
IgG
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Immunogen
Peptide
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Purification
Protein A
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Conjugation
Unconjugated
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Modification
Butyrylated
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Form
Liquid
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Buffer System
Liquid in PBS, Glycerol and BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.