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Product Name
Butyryl-Histone H2A (Lys5) Rabbit pAb
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Gene ID
3012
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SwissProt ID
P04908
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Gene Name
H2AC4
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Alternative Names
H2AK5bu, Histone H2A.2;Histone H2A/a;Histone H2A/m
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Background
Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. Butyrylation of lysineis a newly identified reversible modification controllingchromosome structure and gene transcription. Lysinebutyrylation is highly conserved in eukaryotic cells fromworm to human. The unique structure and genomic localization of histone lysine butyrylation suggest that it is mechanistically and functionally different from histonelysine acetylation. Specifically, in both human somatic andrabbit male germ cell genomes, histone butyrylation marks either active promoters or potential enhancers. Butyrylation of histone H3 at Lys18 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse
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Application
WB,IHC-P
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Dilution Ratio
WB:1/500-1/1000 IHC-P:1/50-1/100
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Molecular Weight
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Clonality
Polyclonal Antibody
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Clonality No.
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Isotype
IgG
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Immunogen
Peptide
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Purification
Protein A
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Conjugation
Unconjugated
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Modification
Butyrylated
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Form
Liquid
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Buffer System
Liquid in PBS, Glycerol and BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.