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Product Name
Butyryl-Histone H2A (Lys5) Mouse mAb
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Gene ID
3012
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SwissProt ID
P04908
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Gene Name
H2AC4
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Alternative Names
H2AK5bu, Histone H2A.2;Histone H2A/a;Histone H2A/m
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Background
Histones are subjected to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. Butyrylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. Lysine butyrylation is highly conserved in eukaryotic cells from worm to human. The unique structure and genomic localization of histone lysine butyrylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Specifically, in both human somatic and rabbit male germ cell genomes, histone butyrylation marks either active promoters or potential enhancers. Butyrylation of histone H2A at Lys5 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA transcriptional regulation.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human,Mouse,Rat
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Application
WB
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Dilution Ratio
WB:1/500-1/1000
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Molecular Weight
-
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Clonality
Monoclonal Antibody
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Clonality No.
9U4-H8-S2
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Isotype
IgG
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Immunogen
Peptide
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Purification
Protein G
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Conjugation
Unconjugated
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Modification
Butyrylated
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Form
Liquid
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Buffer System
Liquid in PBS, Glycerol and BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.