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Product Name
Armenian Hamster Anti-Mouse TCR gamma/delta mAb (PE)
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Gene ID
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SwissProt ID
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Gene Name
Mouse TCR γ/δ
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Alternative Names
TCR-γ/δ; γ/δ TCR
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Background
T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR γ/δ belongs to the immunoglobulin superfamily, involved in the recognition of certain bacterial and tumor antigens bound to MHC class I. The TCR γ/δ associates with CD3e and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are CD4-/CD8-, some are CD8+. T cells expressing the TCR γ/δ have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported that γ/δ T cells also play a principal role in antigen presentation. Immobilized UC7-13D5 antibody has been reported to activate TCR-γ/δ-bearing T cells in vitro, and to deplete peripheral TCR-γ/δ-bearing T cells in vivo.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Flowcytometry
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Host
Armenian Hamster
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Reactivity
Mouse
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Application
FC
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Dilution Ratio
FC: 5μL per test for million cells or whole blood in 100 μL volume.
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Molecular Weight
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Clonality
Monoclonal antibody
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Clonality No.
UC7-13D5
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Isotype
IgG
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Immunogen
A synthesized peptide derived from Mouse TCR γ/δ
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Purification
Affinity Purified
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Conjugation
PE
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS with 0.05% Proclin300, 1% BSA
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Storage
Store at 2-8℃ and protected from prolonged exposure to light. Avoid freeze/thaw cycles.