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Product Name
beta Amyloid 1-42 Mouse mAb
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Gene ID
351
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SwissProt ID
P05067
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Gene Name
A4
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Alternative Names
Abeta42,Amyloid-beta protein 42,Beta amyloid protein 42,Beta APP42,
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Background
Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu2+ and Fe3+ to Cu+ and Fe2+, respectively. Amyloid-beta protein 42 is a more effective reductant than amyloid-beta protein 40. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. APP42-beta may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.
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Research Field
Neuroscience
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Product Categories
Primary antibody
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Host
Mouse
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Reactivity
Human
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Application
WB,ELISA
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Dilution Ratio
WB: 1/500-1/1000 ELISA: 1/1000
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Molecular Weight
Calculated MW: 4.4 kDa; Observed MW: 90-130 kDa crosslinked with BSA
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Clonality
Monoclonal Antibody
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Clonality No.
16D13
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Isotype
IgG2b
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Immunogen
Human beta Amyloid peptide
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS containing 0.09% sodium azide as a preservative.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.