产品详情
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Product Name
PD-L1 Mouse mAb
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Gene ID
29126
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SwissProt ID
Q9NZQ7
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Gene Name
CD274
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Alternative Names
PD-L1; CD274; B7-H1; PDCD1L1; PDCD1LG1
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Background
Swiss-Prot Acc.Q9NZQ7.PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belongs to the B7 superfamily that inhibits immune responses through its receptor, PD-1 and PD-L1 play a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation and in numerous autoimmune diseases.
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Research Field
Immunology
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Product Categories
Flowcytometry
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Host
Mouse
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Reactivity
Human
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Application
FC
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Dilution Ratio
FC: 1/100
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Molecular Weight
-
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Clonality
Monoclonal Antibody
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Clonality No.
FC-H9
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Isotype
IgG2a
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Immunogen
A synthesized peptide derived from human PD L1
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
0.01M PBS, pH 7.4, 0.2%(w/v) BSA, 0.09%(w/v) NaN3
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
应用缩写
WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定
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