产品详情
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Product Name
Anti-PD-L1 [Avelumab]
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Gene ID
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SwissProt ID
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Gene Name
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Alternative Names
Programmed cell death 1 ligand 1; Cd274; PDCD1 ligand 1; Programmed death ligand 1; B7 homolog 1; B7-H1; B7h1; Pdcd1l1; Pdcd1lg1; Pdl1; PDL-1
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Background
Avelumab biosimilar is a programmed death ligand-1 (PD-L1) blocking antibody and prevents its interaction with the inhibitory T-cell receptor, PD-1 (programmed cell death protein 1). Upon binding, avelumab promotes T-cell reactivation and restores T-cell-mediated immune response against tumor cells. Avelumab is also the only PD-L1 antibody so far to also induce antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells expressing PD-L1.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Humanized
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Reactivity
Human
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Application
Functional Assay
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Dilution Ratio
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Molecular Weight
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Clonality
Monoclonal Antibody
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Clonality No.
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Isotype
IgG1
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Immunogen
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
0.01M PBS, pH 7.2
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Storage
This solution is stable for at least 4 weeks when stored at 2-8°C. For long term storage aseptically aliquot and store at –80°C. Avoid repeated freeze/thaw cycles.
应用缩写
WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定
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