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Product Name
MEK7 Rabbit mAb
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Gene ID
5609
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SwissProt ID
O14733
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Gene Name
MAP2K7
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Alternative Names
MAP2K7; JNKK2; MEK7; MKK7; PRKMK7; SKK4; Dual specificity mitogen-activated protein kinase kinase 7; MAP kinase kinase 7; MAPKK 7; JNK-activating kinase 2; MAPK/ERK kinase 7; MEK 7; Stress-activated protein kinase kinase 4; SAPK kinase 4; S
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Background
MKK7 is strongly activated by TNF-α, as well as other environmental stresses, whereas SEK1/MKK4, which activates both p38 and SAPK/JNK pathways, is not activated by TNF-α. Sequence alignment of the activation loop of the MAP kinase kinase family members indicates that Ser271 and Thr275 are potential phosphorylation sites that are crucial for the kinase acivity.
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Research Field
Signal Transduction
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human, Mouse, Rat
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Application
WB,IHC-F,IHC-P,FC
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 FC: 1/50-1/100
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Molecular Weight
Calculated MW:48 kDa;Observed MW: 48 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R03-2N-8
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Isotype
IgG
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Immunogen
Peptide
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.