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Product Name
CRM1 Rabbit mAb
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Gene ID
7514
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SwissProt ID
O14980
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Gene Name
XPO1
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Alternative Names
XPO1; CRM1; Exportin-1; Exp1; Chromosome region maintenance 1 protein homolog
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Background
Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins.
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Research Field
Signal Transduction
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Rat
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Application
WB,ICC/IF
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Dilution Ratio
WB: 1/500-1/1000 IF: 1/50-1/200
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Molecular Weight
Calculated MW: 123 kDa; Observed MW: 123 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R03-4G6
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Isotype
IgG
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Immunogen
A synthetic peptide of human CRM1
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.