-
Product Name
Cyclooxygenase 2 Rabbit mAb
-
Gene ID
5743
-
SwissProt ID
P35354
-
Gene Name
PTGS2
-
Alternative Names
COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS
-
Background
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
-
Research Field
Cardiovascular
-
Product Categories
Primary antibody
-
Host
Rabbit
-
Reactivity
Human,Mouse
-
Application
WB,IP
-
Dilution Ratio
WB: 1/500-1/1000 IP: 1/20
-
Molecular Weight
Calculated MW: 69 kDa; Observed MW: 74 kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
R05-2I3
-
Isotype
IgG
-
Immunogen
Recombinant protein of human COX2/Cyclooxygenase 2
-
Purification
Affinity Purified
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.