产品详情
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Product Name
RAGE Rabbit mAb
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Gene ID
177
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SwissProt ID
Q15109
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Gene Name
AGER
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Alternative Names
AGER; RAGE; Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products
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Background
The receptor for advanced glycation end products (RAGE) is member of the immunoglobulin (Ig) superfamily. Mediates interactions of advanced glycosylation end products (AGE). Binding of AGEs to RAGE results in the induction of cellular oxidant stress and activation of the transcription factor NFkB. Evidence suggests that the induction of oxidant stress results in the activation of an intracellular cascade involving p21 ras and MAP kinase, which leads to activation of transcription.
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Research Field
Neuroscience
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Mouse
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Application
WB
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 43 kDa; Observed MW: 55 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R06-2H4
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Isotype
IgG
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Immunogen
A synthetic peptide of human RAGE
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
应用缩写
WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定
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