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Product Name
Phospho-AKT (Ser473) Rabbit mAb
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Gene ID
207
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SwissProt ID
P31749
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Gene Name
AKT1
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Alternative Names
AKT1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha
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Background
Akt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis. This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase. Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 and by phosphorylation within the carboxy terminus at Ser473.
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Research Field
Neuroscience
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB
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Cited
IF (Human)
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 56 kDa; Observed MW: 56 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R01-4H6
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Isotype
IgG
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Ser473 of human AKT1
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.