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Product Name
Prostaglandin D Synthase Rabbit mAb
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Gene ID
5730
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SwissProt ID
P41222
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Gene Name
PTGDS
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Alternative Names
PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS
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Background
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-Tis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
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Research Field
Signal Transduction
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB,IHC-F,IHC-P,ICC/IF
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
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Molecular Weight
Calculated MW: 21 kDa; Observed MW: 26 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R06-1C5
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Isotype
IgG
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Immunogen
A synthetic peptide of human Prostaglandin D Synthase
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.