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Product Name
BRAT1 Rabbit mAb
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Gene ID
221927
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SwissProt ID
Q6PJG6
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Gene Name
BRAT1
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Alternative Names
BRCA1-associated ATM activator 1; BRCA1-associated protein required for ATM activation protein 1
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Background
Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994).
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human
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Application
WB,IP
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Dilution Ratio
WB: 1/500-1/1000 IP: 1/20
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Molecular Weight
Calculated MW: 88 kDa; Observed MW: 88 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R02-5A1
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Isotype
IgG
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Immunogen
Recombinant protein of human BRAT1
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.