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Product Name
Phospho-Phospholamban (Ser16) Rabbit mAb
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Gene ID
5350
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SwissProt ID
P26678
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Gene Name
PLN
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Alternative Names
PLN; PLB; Cardiac phospholamban; PLB
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Background
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
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Research Field
Signal Transduction
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse
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Application
WB
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 6 kDa; Observed MW: 12,24 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R03-1I4
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Isotype
IgG
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Ser16 of human Phospholamban
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.