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Product Name
KDM1A Rabbit mAb
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Gene ID
23028
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SwissProt ID
O60341
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Gene Name
KDM1A
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Alternative Names
KDM1A; AOF2; KDM1; KIAA0601; LSD1; Lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2
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Background
Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Hamster,Rat
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Application
WB,ICC/IF,IP
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Dilution Ratio
WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
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Molecular Weight
Calculated MW: 93 kDa; Observed MW: 110 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R08-3J5
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Isotype
IgG
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Immunogen
A synthetic peptide of human KDM1/LSD1
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.