-
Product Name
UHRF1 Rabbit mAb
-
Gene ID
29128
-
SwissProt ID
Q96T88
-
Gene Name
UHRF1
-
Alternative Names
Np95; hNP95; ICBP90; RNF106
-
Background
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
-
Research Field
Epigenetics and Nuclear Signaling
-
Product Categories
Primary antibody
-
Host
Rabbit
-
Reactivity
Human
-
Application
WB,IP
-
Dilution Ratio
WB: 1/500-1/1000 IP: 1/20
-
Molecular Weight
Calculated MW: 90 kDa; Observed MW: 97 kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
R06-1C4
-
Isotype
IgG
-
Immunogen
Recombinant protein of human UHRF1
-
Purification
Affinity Purified
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.