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Product Name
Argonaute 2 Rabbit mAb
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Gene ID
27161
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SwissProt ID
Q9UKV8
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Gene Name
AGO2
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Alternative Names
Ago 2; Argonaute 2; dAgo2; eIF2C 2; hAgo2; PPD
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Background
Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). Can also upregulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and upregulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Recombinant Rabbit Monoclonal antibody
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Host
Rabbit
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Reactivity
Human,Rat
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Application
WB
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Dilution Ratio
WB: 1/500-1/1000
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Molecular Weight
Calculated MW: 97 kDa; Observed MW: 97 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R08-6F8
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Isotype
IgG
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Immunogen
A synthetic peptide of human Argonaute-2
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.