-
Product Name
MERTK Rabbit mAb
-
Gene ID
10461
-
SwissProt ID
Q12866
-
Gene Name
MERTK
-
Alternative Names
MERTK; MER; Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK
-
Background
MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
-
Research Field
Neuroscience
-
Product Categories
Primary antibody
-
Host
Rabbit
-
Reactivity
Human
-
Application
WB,IHC-P,IP
-
Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/50
-
Molecular Weight
Calculated MW: 110 kDa; Observed MW: 188 kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
R04-9I7
-
Isotype
IgG
-
Immunogen
A synthesized peptide derived from human MERTK
-
Purification
Affinity Chromatography
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.