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Product Name
Torsin 1A Rabbit mAb
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Gene ID
1861
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SwissProt ID
O14656
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Gene Name
TOR1A
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Alternative Names
TOR1A; DQ2; DYT1; TorsinA
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Background
The neurological condition Dystonia is associated with sustained muscle contractions and abnormal posturing. TorsinA, torsinB, torp2A and torp3A belong to the family of ATPases associated with cellular activites (AAA+) and mutations in torsinA cause early onset dystonia. TorsinA has been shown to suppress intracellular protein aggregation in C. elegans and possesses chaperon activity. Interestingly, torsinA is highly expressed in dopaminergic neurons and associates with alpha-synuclein in Lewy bodies, which pathologically characterize Parkinson's Disease.
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Research Field
Neuroscience
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human
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Application
WB,FC
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Dilution Ratio
WB: 1/500-1/1000 FC: 1/50-1/100
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Molecular Weight
Calculated MW: 38 kDa; Observed MW: 35 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R08-3H1
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human Torsin A
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.