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货号： R26947

别名： LMNA; LMN1; Prelamin-A/C

应用： WB,IHC-F,IHC-P,ICC/IF

反应种属： Human,Mouse

目录价格：

RMB(含税报价)

数量： - + （库存件）

查看代理商预计货期：现货说明书PDF

产品详情

Product Name

Lamin A/C Rabbit mAb
Gene ID

4000
SwissProt ID

P02545
Gene Name

LMNA
Alternative Names

LMNA; LMN1; Prelamin-A/C
Background

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
Research Field

Tags & Cell Markers
Product Categories

Primary antibody
Host

Rabbit
Reactivity

Human,Mouse
Application

WB,IHC-F,IHC-P,ICC/IF
Dilution Ratio

WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
Molecular Weight

Calculated MW: 74 kDa; Observed MW: 74,63 kDa
Clonality

Monoclonal Antibody
Clonality No.

R07-1I5
Isotype

IgG
Immunogen

A synthetic peptide of human Lamin A/C
Purification

Affinity Purified
Conjugation

Unconjugated
Modification

Unmodified
Form

Liquid
Buffer System

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

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验证详情

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应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用，请参照上方的缩写含义，仔细对照后选择合适的产品。

引用文献更多完整详情

标题： Mu‐KRAS attenuates Hippo signaling pathway through PKCι to sustain the growth of pancreatic cancer

样本种属： Human

杂志： JOURNAL OF CELLULAR PHYSIOLOGY

应用： WB

IF： 6.384

文献链接