-
Product Name
KMT6 Rabbit mAb
-
Gene ID
2146
-
SwissProt ID
Q15910
-
Gene Name
EZH2
-
Alternative Names
WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A; EZH2
-
Background
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
-
Research Field
Epigenetics and Nuclear Signaling
-
Product Categories
Primary antibody
-
Host
Rabbit
-
Reactivity
Human
-
Application
WB
-
Dilution Ratio
WB: 1/500-1/1000
-
Molecular Weight
Calculated MW: 85 kDa; Observed MW: 98 kDa
-
Clonality
Monoclonal Antibody
-
Clonality No.
R08-5C6
-
Isotype
IgG
-
Immunogen
Recombinant protein of human KMT6/EZH2
-
Purification
Affinity Purified
-
Conjugation
Unconjugated
-
Modification
Unmodified
-
Form
Liquid
-
Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.