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Product Name
HMG4 Rabbit mAb
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Gene ID
3149
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SwissProt ID
O15347
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Gene Name
HMGB3
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Alternative Names
HMG4; HMG-4; HMG2A; HMG-2a
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Background
Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters . Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor . Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling .
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB,IHC-P,IP
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Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20
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Molecular Weight
Calculated MW: 23 kDa; Observed MW: 23 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R08-1C7
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Isotype
IgG
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Immunogen
A synthetic peptide of human HMG4
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.