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Product Name
Nectin 2 Rabbit mAb
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Gene ID
5819
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SwissProt ID
Q92692
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Gene Name
NECTIN2
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Alternative Names
NECTIN2;HVEB, PRR2, PVRL2;CD112;Nectin-2;Herpes virus entry mediator B (Herpesvirus entry mediator B; HveB);Nectin cell adhesion molecule 2;Poliovirus receptor-related protein 2
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Background
Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705).
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Research Field
Immunology
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human
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Application
IHC-P
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Dilution Ratio
IHC: 1/100-1/200
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Clonality
Monoclonal Antibody
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Clonality No.
R03-9M-7
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Isotype
IgG
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Immunogen
Recombinant protein of human Nectin 2
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.