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Product Name
ErbB 3 Rabbit mAb
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Gene ID
2065
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SwissProt ID
P21860
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Gene Name
ERBB3
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Alternative Names
ERBB3; HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3
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Background
This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation.
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Research Field
Cancer
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Rat
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Application
WB,IP
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Dilution Ratio
WB: 1/500-1/1000 IP: 1/30
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Molecular Weight
Calculated MW: 148 kDa; Observed MW: 185 kDa
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Clonality
Monoclonal Antibody
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Clonality No.
R04-8J6
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Isotype
IgG
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Immunogen
A synthesized peptide derived from human ErbB (HER3)
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Unmodified
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Form
Liquid
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Buffer System
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.